This piece first appeared on AlterNet:
For several years I have postulated that marijuana is not, in the strict sense of the word, an intoxicant.
As I wrote in the book Marijuana Is Safer: So Why Are We Driving People to Drink? (Chelsea Green, 2009), the word ‘intoxicant’ is derived from the Latin noun toxicum (poison). It’s an appropriate term for alcohol, as ethanol (the psychoactive ingredient in booze) in moderate to high doses is toxic (read: poisonous) to healthy cells and organs.
Of course, booze is hardly the only commonly ingested intoxicant. Take the over-the-counter painkiller acetaminophen (Tylenol). According to the Merck online medical library, acetaminophen poisoning and overdose is “common,” and can result in gastroenteritis (inflammation of the gastrointestinal tract) “within hours” and hepatotoxicity (liver damage) “within one to three days after ingestion.” In fact, less than one year ago the U.S. Food and Drug Administration called for tougher standards and warnings governing the drug’s use because “recent studies indicate that unintentional and intentional overdoses leading to severe hepatotoxicity continue to occur.”
By contrast, the therapeutically active components in marijuana — the cannabinoids — appear to be remarkably non-toxic to healthy cells and organs. This notable lack of toxicity is arguably because cannabinoids mimic compounds our bodies naturally produce — so-called endocannabinoids — that are pivotal for maintaining proper health and homeostasis.
In fact, in recent years scientists have discovered that the production of endocannabinoids (and their interaction with the cannabinoid receptors located throughout the body) play a key role in the regulation of proper appetite, anxiety control, blood pressure, bone mass, reproduction, and motor coordination, among other biological functions.
Just how important is this system in maintaining our health? Here’s a clue: In studies of mice genetically bred to lack a proper endocannabinoid system the most common result is premature death.
Armed with these findings, a handful of scientists have speculated that the root cause of certain disease conditions — including migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis — may be an underlying endocannabinoid deficiency.
Now, much to my pleasant surprise, Fox News Health columnist Chris Kilham has weighed in on this important theory.
If the idea of having a marijuana deficiency sounds laughable to you, a growing body of science points at exactly such a possibility.
… [Endocannabinoids] also play a role in proper appetite, feelings of pleasure and well-being, and memory. Interestingly, cannabis also affects these same functions. Cannabis has been used successfully to treat migraine, fibromyalgia, irritable bowel syndrome and glaucoma. So here is the seventy-four thousand dollar question. Does cannabis simply relieve these diseases to varying degrees, or is cannabis actually a medical replacement in cases of deficient [endocannabinoids]?
… The idea of clinical cannabinoid deficiency opens the door to cannabis consumption as an effective medical approach to relief of various types of pain, restoration of appetite in cases in which appetite is compromised, improved visual health in cases of glaucoma, and improved sense of well being among patients suffering from a broad variety of mood disorders. As state and local laws mutate and change in favor of greater tolerance, perhaps cannabis will find it’s proper place in the home medicine chest.
Perhaps. Or maybe at the very least society will cease classifying cannabis as a ‘toxic’ substance when its more appropriate role would appear to be more like that of a supplement.
Not to mention all the cancers that are seemingly inflicting huge numbers of people now days. Cancers that can not grow in the presence of THC cannabinoids.
Nonsense. If Pot cured, or prevented cancer, then no pot smoker would ever die from cancer.
many people with canncer are not responsive to cannabis because the genes that code for cannabinoid receptors are methylated. What this means is that those genes are silenced and cannabinoid receptors aren’t being made. An endocannainoid deficient person must first unmethylate their genes, with either a prescription drug or natural alternatives like EGCG in green tea. Then their body will make CB1 & CB2 receptors that will respond to cannabis.
Raw cannabinoids like THCA and CBDA in raw cannabis juice do not interact with CB1 & CB2 and therefore are helpful even in people who have methylated genes. For more information read my book Vitamin Weed: Get Healthy, Not High: http://www.drmicheleross.com/book
“many people with canncer [sic] are not responsive to cannabis because …”
marijuana does not cure cancer.
http://www.addictinginfo.org/2015/08/22/national-cancer-institute-finally-concedes-cannabis-kills-cancer/
I was feeling a bit deficient a few minutes ago but I’m better now.
This was confirmed in June 2014, some 10 years after Dr Ethan Russo first posited it.
http://www.ncbi.nlm.nih.gov/pubmed/24977967
“Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Smith SC, Wagner MS.
Abstract
OBJECTIVES: Ethan B. Russo’s paper of December 1, 2003 explored the concept of a clinical endocannabinoid deficiency (CECD) underlying the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome and other functional conditions alleviated by clinical cannabis.
METHODS: Available literature was reviewed, including searches via the National Library of medicine database and other sources.
RESULTS: A review of the literature indicates that significant progress has been made since Dr. Ethan B. Russo’s landmark paper, just ten years ago (February 2, 2004). Investigation at that time suggested that cannabinoids can block spinal, peripheral and gastrointestional mechanisms that promote pain in headache, fibromyalgia, irritable bowel syndrome and muscle spasm.
CONCLUSION: Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions. Clinical experience is bearing this out. Further research and especially, clinical trials will further demonstrate the usefulness of medical cannabis. As legal barriers fall and scientific bias fades this will become more apparent.”
I expand on this in my book Vitamin Weed: Get Healthy, Not High show you how to reverse endocannabinoid deficiency: http://www.drmicheleross.com/book
Hey Paul–Do you still stand by the unscientific 5 nano-gram THC ‘impairment’ limit national NORML introduced to CO? I heard you arguing with Rico Colibri (now Garcia) on a radio show claiming any more THC impaired people. And Claire Levy (D) Boulder definitely said at a recorded town hall that we should be happy because NORML brought the language to her and NORML said it was the highest in the nation….
NORML = the prohibitionist lobbying arm of the Criminal Trial Lawyers Association who make MILLIONS of $$ defending suckers from unnecessary criminal laws against marijuana they helped create and sustain.
My book Vitamin Weed: Get Healthy, Not High shows you how to reverse endocannabinoid deficiency: http://www.drmicheleross.com/book
Not just in the medicine cabinet but more importantly in the kitchen!
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