Ibogaine, an alkaloid derived from the root of a rain forest shrub, has been recognised for its ability to promote long term drug abstinence after only a single dose.
A University of Miami study verified anecdotal reports that a single dose of ibogaine can eliminate opiate withdrawal, reduce drug craving for extended periods of time, and decrease depressive symptoms.
Ibogaine has shown preliminary efficacy for opiate detoxification and for short-term stabilization of drug-dependent persons as they prepare to enter substance abuse treatment. We report here that ibogaine significantly decreased craving for cocaine and heroin during inpatient detoxification. Self-reports of depressive symptoms were also significantly lower after ibogaine treatment and at 30 days after program discharge. Because ibogaine is cleared rapidly from the blood, the beneficial aftereffects of the drug on craving and depressed mood may be related to the effects of noribogaine on the central nervous system.