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The Biochemist Who Cured His Cancer With Cannabis Oil

 
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by Luke Sumpter

on September 17, 2015

Vast amounts of people are coming forward to testify as to how they have treated — and in some cases completely cured — serious diseases with cannabis extracts. These personal testimonials even cover diseases that the medical establishment often fails to effectively treat, such as cancer.

Despite a deficiency in human trials, there are a significant amount of studies that show compounds found within cannabis, known as cannabinoids, have anti-cancer properties. The United States’ federally funded National Institute of Health even goes as far as to state on their website that: “Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.”

To gain both a greater personal and scientific insight into the cancer-fighting prowess of cannabis, Reset spoke to Dennis Hill who, having earned a degree in biochemistry from the University of Houston, has worked in medical research at the University of Texas’ M.D. Anderson Cancer Center. Hill currently resides in California, where he now works in software engineering.

Photo: Dennis Hill

Photo: Dennis Hill

Following a biopsy in 2010, Hill was diagnosed with aggressive Stage 4 adenocarcinoma of the prostate, with Gleason scores of 7s and 8s. A digital exam also revealed metastatic lesions in the bladder and rectum.

We asked Hill what approach he took to treating the disease. “Opting out of radiation, chemo and surgery, I chose cannabis extract,” replies Hill. “Within six months the cancer was in remission.”

How did Hill achieve this truly staggering result? “I never really noticed any dramatic changes; the cancer just went away,” he tells us. “After three months, the primary tumor was gone; after three more months, the metastatic lesions were gone.”

So how exactly does cannabis work in the body? Hill, utilizing his expert knowledge of human biochemistry, explains to us in detail exactly what occurs when a cancer patient ingests cannabinoids:

“Let us look first at tetrahydrocannabinol (THC) and observe that THC is a natural fit for the CB1 cannabinoid receptor on the cancer cell surface. When THC hits the receptor, the cell generates ceramide that disrupts the mitochondria, closing off energy for the cell. Disruption of the mitochondria releases cytochrome c and reactive oxygen species into the cytosol, hastening cell death. It is notable that this process is specific to cancer cells. Healthy cells have no reaction to THC at the CB1 receptor. The increase in ceramide also disrupts calcium metabolism in the mitochondria, completing the demise to cell death.

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“The other cannabinoid we know is effective in killing cancer cells is cannabidiol (CBD). The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum through the wrecking of the calcium metabolism, pushing calcium into the cytosol. This always results in cell death. Another pathway for CBD to effect cancer cell death is the caspase cascade, which breaks down proteins and peptides in the cell. When this happens the cell cannot survive. Again, these processes are specific to cancer cells, no normal cells are affected.”

Hill goes on to explain how certain cannabinoids destroy cancerous tumors by working symbiotically with our body’s endocannabinoid system:

“The endocannabinoid system (ECS) started revealing itself to researchers in the 1940s and by the late ‘60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, somatic tissues, and all metabolic biochemical systems, including the immune system.

“This homeostatic matrix is not a recent evolutionary twist just for humans; we find the endocannabinoid system in every chordate creature for the last 500 million years. It is a fully mature biochemical technology that has maintained health and metabolic balance for most of the history of life itself.

endocannabinoid-natur

“The two major interactive systems within the ECS are one, the cannabinoid receptors that we find on all cell surfaces and neurological junctions and two, the endocannabinoids that fit the receptors to trigger various metabolic processes. Looking at a cannabinoid receptor distribution map we see that CB1 receptors, that are most sensitive to anandamide, are found in the brain, spinal nerves, and peripheral nerves. CB2 receptors preferred by 2-Arachidonoylglycerol (2-AG) are found largely in the immune system, primarily the spleen. A mix of CB1 and CB2 receptors are found throughout the rest of the body including the skeletal system. And yes, 2-AG or CBD will grow new trabecular bone. It is also useful to note that both anandamide and 2-AG can activate either CB1 or CB2 receptors.

“The nature of the endocannabinoids are functionally much like neurotransmitters, but structurally are eicosanoids in the family of signaling sphingolipids. These signaling cannabinoids keep track of metabolic systems all over the body. This information is shared with the nervous system and the immune system so that any imbalance is attended to. If the body is in chronic disease or emotional stress, the immune system can fall behind and lose control of compromised systems. It is here that phytocannabinoids can pitch in to support the stressed body in a return to health. The cannabis plant provides analogues of the body’s primary signaling cannabinoids. Tetrahydrocannabinol (THC) is mimetic to anandamide, and cannabidiol (CBD) is mimetic to 2-AG, and has the same affinity to CB1 and CB2 receptors, providing the body with additional support for the immune and endocannabinoid systems.

“Phytocannabinoids supercharge the body’s own endocannabinoid system by amping up the response to demand from the immune signaling system in two modes of intervention: one, of course, is in bonding with the cannabinoid receptors; the other is in regulation of innumerable physiological processes, such as cannabinoid’s powerful neuroprotective and anti-inflammatory actions, quite apart from the receptor system. It is interesting to note here that the phytocannabinoids and related endocannabinoids are functionally similar, but structurally different. As noted above, anandamide and 2-AG are eicosanoids while THC and CBD are tricyclic terpenes.

“The National Institutes of Health tells us that THC is the best known because of its signature psychotropic effect. This government report shows THC to be effective as an anticancer treatment, an appetite stimulant, analgesic, antiemetic, anxiolytic, and sedative. There is a plentiful supply of research articles and personal testaments that show the efficacy of cannabis effecting cancer remission. However, only a few point to the mechanism by which the cancer cells die. To understand this better we need to know what metabolic processes provide life to the cells.

“There are two structures in most cells that sustains life; one is the mitochondria, and the other is the endoplasmic reticulum. The mitochondria primarily produce adenosine triphosphate (ATP) that provides the necessary energy. The endoplasmic reticulum (ER) is a loosely bound envelope around the cell nucleus that synthesizes metabolites and proteins directed by the nuclear DNA that nourish and sustain the cell…

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“In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the ‘Sphingolipid Rheostat.’ If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality. Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.

“The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.

“Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.

“The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.

“How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for it’s matched exocannabinoid activator.

“This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis: our wellbeing…

“Endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.

“To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica can be higher in CBD (cannabidiol).

“It is known that THC and CBD are biomimetic to anandamide and AG-2, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.

“Typically CBD gravitates to the 5-HT1A and vanilloid receptors. CBD stimulates production of anandamide and AG-2, endogenous cannabinoids that are agonists for CB-1 and CB-2 receptors. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide re-uptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.

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“In 2006, researchers in Italy showed the specifics of how cannabidiol (CBD) kills cancer. CBD stimulates what is known as the Caspase Cascade, that kills the cancer cell. First, let’s look at the nomenclature, then to how Caspase kills cancer. Caspase in an aggregate term for all cysteine-aspartic proteases. The protease part of this term comes from prote (from protein) and -ase (destroyer). Thus the caspases break down proteins and peptides in the moribund cell. This becomes obvious when we see caspase-3 referred to as the executioner. In the pathway of apoptosis, other caspases are brought in to complete the cascade.

“Even when the cascade is done and all the cancer is gone, CBD is still at work healing the body. Cannabidiol also shuts down the Id-1 gene; a gene that allows metastatic lesions to form. Fundamentally this means that treatment with cannabinoids not only kills cancer through numerous simultaneous pathways, but prevents metastasis. What’s not to like… Nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.”

Finally, Reset asked what advice Hill would dispense to somebody with terminal cancer who is looking into the possibility of utilizing cannabis oil. He replies, “Many who have sought out cannabis as a last resort have recovered. It’s never too late.”

 

Below is a video of Dennis Hill explaining how cannabinoids cause cancer cells to die:

  • David W. Eastridge

    The question is what is a therapeutic dose for the oil

  • http://www.localnlive.co.uk/ heenan73

    Embarassing pseudoscience.
    I completely agree that decent scientific studies are long overdue, and – speaking as someone living with cancer – the sooner the better.
    But to kill time by publishing personal stories doesn’t do it – and claiming this lab tech is a biochemist is both a lie and a “so what”.
    Personal stories prove nothing – that’s why research is so important. Any number of things could have given him remission, we just don’t know.
    You’ll be telling us next that he prayed every day.

  • ChristopherSawtell

    60 grammes of the pure oily resin over 60 days. Start slowly! 30 mg divided into 3 doses per day. Double the dose every 4 days, as you are able, until you get to 333 mg per dose. You need a pure Indica strain!!
    If you are infected with a cronic microbe infection of some kind take even less at the start. You will feel sleepy, so retire to your cot because extended sleep & rest is a vital part of the treatment.

  • ChristopherSawtell

    10,000 personal testimonies does it for me.

  • Ruger883

    Kind of like personal stories of how aspartame harms people means nothing. 500+ studies shows it does not.

  • David W. Eastridge

    If we don’t share our experiences in life ….who will tell us what is going on ,, the Gov.. want us in the dark,,,,Fear is the lack of Knowledge,,,,, lets illuminate the dark shadow of fear with the Bright Light of Knowledge…10,000 personal testimonies does it for me tooooooooooooooooooo,,,before there were Dr’s there were only personal stories!!!!! Mahalo for the info ChristopherSawtell

  • http://www.localnlive.co.uk/ heenan73

    This is ONE personal story, dressed up as science. But hey, you want gullible, be my guest.

  • Ed Bland

    WAKE-UP !

    ~ When eaten THC brings the body’s PH level up to 7.2 where CANCER dies ! THAT SIMPLE !

    ~ I am a HEALER that was “returned” to HEAL EARTH ~ I want 2 HEAL, not go 2 PRISON !

    Here is the sad truth that the media refuses to share. I was drinking because of neck pain from disc removal. I was addicted to OPIATES. I wrecked a harley killing me 3 times in life flight being shocked back every time. Receiving an 87 day coma, waking with a 5.5 brain injury. It is MARIJUANA that is helping my brain injury heal.

    ~ Since waking from my coma I have refused all pain killers. Even the MORPHINE when they removed the 4 bolts that held the PELVIC BRACE.

    Only MARIJUANA do I use

    It has healed my brain so well that I was able to “reverse engineer” GOLD. The USA could become DEBT FREE.

  • Ed Bland

    GOLD & what makes it.

  • 333888388388

    You’ll get ~60 grams of oil from a pound of bud. It’ll last 90 days if you start slow and work up to a gram a day.

  • 333888388388

    Not necessarily just a pure indica strain. Indica is good, but some hybrids are thought to work just as well. A 1:1 (THC:CBD) strain like cannatonic, or harlequin, or acdc. CBD is important too.

  • Eat More Hemp

    #EatMoreHemp

  • Khali

    Where to buy the oil, how much to take?

  • George

    There’s a small error, in “Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems?”, THC and cannabinol are not enzymes.
    Apart from that, this explanation makes perfect sense. It helps to explain why pot smokers don’t get lung cancer at increased rates (though chemical differences between cannabis smoke and tobacco smoke also help explain that).

  • George

    If you think that changing the body’s pH kills cancer, why don’t you just use bicarbonate of soda? That’s not illegal.
    Apart from that, it looks like you made the right choice going with the herb. Opiates are not good for brain health, due to their TLR4 agonist effects.

  • George

    What a difficult choice. Aspartame or pot.
    Hmmmn. Let me think.

  • Maria Hynes

    The Dr @ the clinic states good for asthma Mayo clinic stated for pain-early 1992 (est) I was told it was lobbing Only the fact they don’t make money from Cannabis They are scared to affect their license. No cancer as of yet.Quit smoking & I believe the pain is worse.

  • jim

    The Republican Party should be PROUD OF THEMSELVES for FIGHTING TO KEEP THIS MEDICINE FROM US!
    THAT IS WORSE THAN TREASON! HOW MANY PEOPLE LIKE MY X MOM – IN-LAW COULD HAVE LIVED INSTEAD OF DYING A SLOW DEATH!
    TO HELL WITH THE REPUBLICAN JUST SAY NO TO EVERYTHING PARTY. IGNORANCE AND RELIGION IS NO EXCUSE TO BE MEAN AND EVIL AS THE DEVIL HIMSELF!

  • Edwin Kano

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    Deliveries 24/7 everywhere!!!! very clean smelling, awesome taste and
    VERY potent Cannabis oil. purged for hours so no impurities left
    Our oils are goods for pain,cancers,insomnia and others diseases
    No effects.
    100% pure Cannabis Oil extracted from top quality marijuana, laboratory tested
    Email us today at dr.mangeljose@gmail.com or text (571) 295-7072

  • ArcherRush

    Im surprised as a Bio Chemist he did not touch on, or maybe
    oddly he does not know the main reason Cannabis shrinks Tumors. Its called
    angiogenesis, which is the process that the
    body uses to create new blood vessels, the way a tumor works is to
    send out chemical signals (VEGFR, VEGF) which starts the
    angiogenesis process and new blood vessels grow into the tumor
    feeding it with oxygen and sugars and also gives it a path to spread throughout
    the body. Cannabis or more exactly CBD is anti-angiogenesis, it prevents the
    formation of new blood vessels in turn starving the cancer
    and causing it to shrink.

  • zlop

    Why Alex Jones is nt selling Cannabis Oil?